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Abemaciclib methanesulfonate (LY2835219) 是一种选择性的CDK4/6抑制剂,能够抑制 CDK4/CDK6 的活性,IC50分别为 2 nM 和 10 nM。
Abemaciclib methanesulfonate (LY2835219) 是一种选择性的CDK4/6抑制剂,能够抑制 CDK4/CDK6 的活性,IC50分别为 2 nM 和 10 nM。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
2 mg | ¥ 251 | 现货 | |
5 mg | ¥ 442 | 现货 | |
10 mg | ¥ 647 | 现货 | |
50 mg | ¥ 946 | 现货 | |
100 mg | ¥ 1,247 | 现货 | |
200 mg | ¥ 1,565 | 现货 |
产品描述 | Abemaciclib methanesulfonate (LY2835219) is a specific and effective inhibitor of CDK4(IC50=2 nM) and CDK6(IC50=10 nM). |
靶点活性 | CDK4:2 nM, CDK6:10 nM |
体外活性 | MsOH处理皮下和颅内胶质瘤模型(U87 mg)中,LY2835219以剂量依赖的方式抑制肿瘤生长. |
体内活性 | 在视网膜母细胞瘤中,LY2835219通过特异性抑制CDK4和6,使细胞周期停滞在G1期,抑制DNA合成,且抑制癌细胞生长。 |
激酶实验 | Cells (5 × 103) are plated in 96 well plates. Cells are treated the next day for 24 to 48 hours and then assessed for caspase-3 activity by Caspase-Glo-3/7 Assay, as per manufacturer's instructions and a luminescence plate reader. |
细胞实验 | LY2835219 is dissolved in DMSO to a 10 mM concentration.? Cells are seeded in a 96-well plate, allowed to adhere overnight, and treated with DMSO control (0.1% v/v) or the indicated compounds for 72 h. Cell viability and proliferation are determined using a Cell Counting Kit according to the manufacturer's instructions. The interaction between LY2835219 and mTOR inhibitor is determined using CompuSyn. Combination index (CI) values of 1 indicates and additive drug interaction, whereas a CI of < 1 is synergistic and a CI of > 1 is antagonistic. |
别名 | abemaciclib mesylate, LY2835219, LY2835219 mesylate, LY2835219 (methanesulfonate) |
分子量 | 602.7 |
分子式 | C27H32F2N8·CH4O3S |
CAS No. | 1231930-82-7 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||||||||||||
溶解度信息 | H2O: 45 mg/mL (74.7 mM) DMSO: 6.03 mg/mL (10 mM), Sonication is recommended. Ethanol: 23 mg/mL (38.2 mM) | ||||||||||||||||||||||||||||||||||||||||
溶液配制表 | |||||||||||||||||||||||||||||||||||||||||
DMSO/Ethanol/H2O
Ethanol/H2O
H2O
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